Melacron Plus Oral Drops

Ingredients ( Per Dropper 0.5 ml )

• – Melatonin 5 mg
• – Tryptophan 15 mg
• – Glycine 7.5  mg                             with Raspberry flavor

Melacron® Plus is a triple neuroactive formulation containing Melatonin, Tryptophan, and Glycine, developed to support sleep regulation, cognitive balance, and comfort in children and adults.
It acts on circadian rhythm restoration, neurotransmitter modulation, and pain control, offering a safe, physiological approach for both neurotypical and neurodivergent patients.

Properties

1. Melatonin : Hypnoinducer and chronobiotic agent.

• • Mechanism: Regulates circadian rhythm by synchronizing the body’s internal clock (suprachiasmatic nucleus).

  • Pharmacological Effects:

• 1- Restores natural sleep–wake cycle.
• 2- Induces sleep without tolerance or addiction.
• 3- Exerts analgesic action by stimulating β-endorphin synthesis, activating GABAergic receptors, and inhibiting TRPV1 nociceptive receptors.

2. Tryptophan: Precursor of melatonin and serotonin.

• Mechanism: Enhances serotonergic neurotransmission, improving mood stability and sleep quality.

• Pharmacological Effects:

  1- Regulates sleep, especially in parasomnias and night terrors.

• 2- Improves attention, cognitive processing, and mood regulation in serotonergic vulnerability (e.g., ADHD, ASD).
• 3-Reduces migraine frequency by stabilizing serotonin-mediated vasoconstriction of cranial vessels.

3. Glycine: Neuroinhibitory amino acid and physiological neurorelaxant.

• Mechanism: Acts on NMDA receptors in the suprachiasmatic nucleus to lower body temperature and promote sleep onset.

• Pharmacological Effects:

  1- Normalizes sleep architecture and improves daytime alertness.

• 2- Enhances cognitive and emotional memory, reduces impulsivity.
• 3- Modulates nociceptive transmission in the spinal dorsal horn—helping relieve pain syndromes such as IBS, migraine, or postoperative pain.

Indications

Melacron® Plus is recommended for:

1- Sleep disorders in neurotypical children (insomnia, parasomnias, delayed sleep phase).

2- Sleep and behavioral disorders in neurodivergent children (Autism Spectrum Disorders, ADHD, tic disorders, Tourette syndrome).

3- Pain syndromes: irritable bowel syndrome, acute/chronic migraine, postoperative pain.

4- Preparation for diagnostic neuroradiology (EEG, MRI, ABR), offering sedation-free calmness and sleep induction.

Directions

Duration: Minimum 30 days.
Long-term therapy (1–4 years) is safe and supports stable chronobiological and developmental outcomes.

• – Melacron® Plus is free from allergens, colorants, sweeteners, gluten, and lactose.
• – Melacron® Plus is not associated with tolerance, no dependence, and no interference with endogenous melatonin production.