– Inulin 1.6 g
– D-mannose (from birch, Betula pendula Roth., bark) 500 mg
– CystiCran™40 – Cranberry (Vaccinium macrocarpon Aiton) fruits d.e.,135 mg titrated to 40% proanthocyanidins 54 mg
– Vitamin C 120 mg
– Pido-Zinc® (Zinc pidolate) 11.2
– Berryvin™ – standardized dry extract of mixed fruits: 20 mg
1. Defensive & Anti-Adhesive Action
Cranberry (Proanthocyanidins) and D-Mannose act synergistically to prevent E. coli adhesion to bladder and urethral walls.
Facilitate detachment of bacteria already adhering to epithelial cells, promoting elimination through urine.
Mechanism: PACs bind fimbriae adhesins of E. coli, while D-Mannose acts as a competitive inhibitor at glycoprotein receptors.
2. Antioxidant Action
Berryvin™ (polyphenols, anthocyanins, ellagic acid) + Vitamin C form a potent antioxidant system.
Neutralizes free radicals produced during infection and protects mucosal cells from oxidative damage.
Reduces inflammation and strengthens mucosal resistance to recurrent infections.
3. Immunomodulating Action
Inulin stimulates the alternative complement pathway, increasing white blood cell activity and immune defense against bacteria and viruses.
Pido-Zinc® ensures high zinc absorption, exerting immunostimulant and anti-radical actions.
4. Repairing & Reconstructive Action
D-Mannose supports the restoration of glycosaminoglycan (GAG) layers of bladder and vaginal mucosa, strengthening mucosal defense and reducing recurrence.
Cistidep® is suitable for:
Acute Phase:
1 sachet twice daily for 8 days
Preferably in the morning (on waking) and evening (after dinner) on an empty bladder
Prevention of Relapse:
1 sachet daily for 8 days each month
Repeat for 4 consecutive months
Take in the evening after dinner, on an empty bladder


