Ingredients ( per one stick )
- Palmitoylethanolamide (PEA, water dispersible) – 1200 mg
- Melatonin – 0.2 mg
Properties
1- Mast Cell Inhibition:
CRC DEP acts by inhibiting mast cell degranulation — reducing the release of pain and inflammatory mediators such as histamine, TNF-α, and IL-6.
This helps break the vicious mast-neural circuit responsible for sustaining chronic pain and neuroinflammation.
2- Dual Mechanism Synergy (PEATONIDE®):
- – Combines Palmitoylethanolamide (PEA, 1200 mg) and Melatonin (0.2 mg) in a 6000:1 ratio.
- – Proven synergistic effect in controlling pain and inflammation via:
- Endocannabinoid system activation (increasing CB1 and CB2 activity).
- Opioid receptor activation (via β-endorphins).
- PPAR-α modulation for long-lasting anti-inflammatory gene regulation.
Indications
CRC DEP is indicated for the management of chronic pain and inflammation associated with:
1 – Fibromyalgia
2 – Osteoarthritis
3 – Chronic Neuropathic Pain
4 – Migraine (moderate to severe)
5 – Irritable Bowel Syndrome (IBS)
6 – Cancer-related pain
- Direction:
- – 1 stick per day, preferably in the evening after meals or at bedtime.
- – Dissolved directly in the mouth, allowing gradual absorption, or
- – Diluted in a glass of water (200 mL) to form a pleasant, drinkable dispersion (cool mint flavor).
